球孢子菌病是美国西南部、犹他州大部及墨西哥北部一种常见的流行性深部霉菌病,每年报告的新病例超过100,000。目前,在美国的非流行地区、加拿大、欧洲、澳洲及日本等地,亦发现有原发和传播的球孢子菌病发生。肺是球孢子菌感染最常受累的器官,也是肺外球孢子菌病的侵入门户。肺球孢子菌病表现各异,通常以Winn等氏法归为以下三个主要综合征:(1)原发性肺球孢子菌病;(2)粟粒样肺球孢子菌病;(3)残余或进行性肺球孢子 Coccidioidomycosis is a common epidemic of deep mycosis that occurs in the southwestern United States, most of Utah and northern Mexico, reporting over 100,000 new cases each year. Currently, non-endemic areas in the United States, Canada, Europe, Australia and Japan, also found that primary and transmitted coccidiosis occurred. The lung is the organ most commonly affected by coccidioidomycosis and is the gateway to the invasion of extra-coccidioidomycosis. Pneumococcal spore disease varies in performance and is usually classified as the following three major syndromes by the Winn’s method: (1) primary pulmonary coccidioidomycosis; (2) miliary-like coccidioidomycosis; (3) Residual or progressive pulmonary coccidia