【摘 要】
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Brain-derived neurotrophic factor (BDNF) is a member of neurotrophin family associated with the proliferation,differentiation,activity-dependent plasticity,and
【机 构】
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Department of Endocrinology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200020,
论文部分内容阅读
Brain-derived neurotrophic factor (BDNF) is a member of neurotrophin family associated with the proliferation,differentiation,activity-dependent plasticity,and survival of neurons in the central nervous system [1].BDNF influences glucose metabolism and insulin sensitivity.For example,BDNF decreases serum glucose,insulin,and HbAlc levels in diabetic rats,suggesting that the BDNF may improve insulin sensitivity.In addition,animal models showed that BDNF levels in the central nervous system are highly related to peripheral serum BDNF levels [2].It was found that BDNF may ameliorate glucose metabolism and prevent pancreatic exhaustion in obese diabetic mice [3].
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