“原始抗原痕迹(original antigenic sin)”首先用于描述对流感病毒的抗体反应。一种病毒初次感染后,再次感染另一种新的病毒株或接种疫苗,将使针对原先感染病毒株的特异性抗体水平增高。虽然这些抗体可与新的病毒发生交叉反应,它们却与初次感染的病毒株有更高的亲和力。原始抗原痕迹“被认为主要是一种抗体现象,然而Klenerman和Zinkernagel用淋巴细胞性脉络丛脑膜炎病 ”Original antigenic sin “ was first used to describe the antibody response to the influenza virus. After a virus is first infected, re-infection with another new virus strain or vaccination will result in an increase in the level of specific antibodies against the originally infected virus strain. Although these antibodies cross-react with new viruses, they have a higher affinity for the first-infected virus strain. The original antigenic mark ”is thought to be primarily an antibody phenomenon, however Klenerman and Zinkernagel use lymphocytic choriomeningitis