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张建忠医师发表在《中级医刊》1986年笫8期上的文章称:“青霉素类与庆大霉素联用时,不能全部甚至根本不能发挥庆大霉素的作用。由于分别注射或间隔给药不能避免药物在体内相遇,故应禁忌联用”。本文提出以下意见与张建忠医师商榷。 1.青、庆联用可以产生协同作用,因此是合理的。根据抗生素作用分类理论来看,青、庆分属于Ⅰ和Ⅱ类,配合使用有利于青、庆分别作用于细菌的不同部位,产生协同作用而大大提高杀菌效力。实验亦证明,青、庆联用有协同作用。有人用一系列不同浓度的抗生素与肠球菌作用24小时后观察杀菌
Zhang Jianzhong published in the “Intermediate Medical Journal,” 1986, the eighth phase of the article said: “Penicillin and gentamicin combination, can not all or even not play the role of gentamicin due to the separate injection or interval administration Can not avoid drugs meet in the body, it should be taboo combined. ” This article put forward the following opinions with Dr. Zhang Jianzhong to discuss. 1. Green, celebrate the use of synergy can produce, it is reasonable. According to the classification theory of antibiotic action point of view, green and celebrate belong to Ⅰ and Ⅱ categories, with the use of green, Qing role in different parts of the bacteria, resulting in synergies and greatly enhance the bactericidal effect. Experiments also prove that green, celebrate with a synergistic effect. Some people use a series of different concentrations of antibiotics and enterococci 24 hours after the observation of sterilization