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目的:探讨热毒宁对重症肺炎患者血浆可溶性髓系细胞触发受体1、白细胞介素10的水平变化与相关性。方法:选取2014年6月—2015年9月本院ICU病房以重症肺炎为诊断收入院的患者86例,根据随机数字表法随机分为两组:对照组43例,予抗炎、化痰等常规治疗;实验组43例,在常规治疗基础上应用热毒宁注射液,共治疗7~10 d。观察两组患者治疗前后血浆可溶性髓系细胞触发受体1、白细胞介素10及血气分析等水平变化,探索热毒宁对重症肺炎患者的有效性及安全性,其数据结果应用统计学软件SPSS 19.0加以处理。结果:治疗前患者血清中s TREM-1和IL~(-1)0的浓度水平呈正相关(r=0.329,P=0.03),经1个疗程治疗后,与对照组比较,实验组患者血清中s TREM-1、IL~(-1)0浓度水平显著降低,体温、呼吸、白细胞降低,血氧分压及氧合指数明显升高,实验组的总有效率(90.70%)明显高于对照组(74.42%),以上结果均有统计学意义(P<0.05)。实验组患者出现不良反应轻微,在停药后消失。结论:热毒宁能够减轻重症肺炎患者血清中炎症反应,改善临床症状体征,且安全性较高。
Objective: To investigate the effect of Revington on plasma soluble myeloid cells triggering receptor 1 and interleukin 10 levels in patients with severe pneumonia. Methods: From June 2014 to September 2015, 86 patients with ICU ward diagnosed as severe pneumonia in our hospital were randomly divided into two groups according to the random number table (control group, 43 cases) with anti-inflammatory and phlegm And other conventional treatment; experimental group of 43 cases, based on the conventional treatment with heat poisoning injection, a total of 7 to 10 days. The changes of plasma soluble myeloid cells trigger receptor 1, interleukin 10 and blood gas analysis were observed before and after treatment in both groups to explore the effectiveness and safety of Revidin in patients with severe pneumonia. The data were analyzed using statistical software SPSS 19.0 to deal with. Results: The levels of s-TREM-1 and IL-1 0 in serum before treatment were positively correlated (r = 0.329, P = 0.03). After one course of treatment, compared with the control group, The concentrations of TREM-1 and IL-1 0 were significantly decreased, and body temperature, respiration, leukopenia, partial pressure of oxygen and oxygenation index were significantly increased. The total effective rate (90.70%) in the experimental group was significantly higher than that in the experimental group The control group (74.42%), the above results were statistically significant (P <0.05). Adverse reactions in the experimental group patients mild, disappeared after stopping. Conclusion: Rendunning can reduce inflammation in patients with severe pneumonia, improve clinical symptoms and signs, and high safety.