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目的：探讨腹腔镜联合胆道镜治疗胆囊结石合并胆总管结石的有效性及安全性。方法选取2012年8月-2013年8月采用腹腔镜联合胆道镜治疗的96例胆囊结石合并胆总管结石患者为观察组，同期采用开腹胆囊切除术治疗的85例患者为对照组，观察两组患者手术情况、并发症情况及血清CRP变化情况。结果观察组术中出血量、肛门排气时间、住院时间及术后并发症发生率均明显低于对照组，P <0.05；观察组治疗后第1d、3d、5d血清CRP水平明显低于对照组，P <0.05。结论腹腔镜联合胆道镜治疗胆囊结石合并胆总管结石疗效好、安全性高。“,”Objective To investigate the safety and potency of treating Gallstones and Choledocholithiasis using Peritoneoscope and Choledochoscope. Methods The 96 cases were chosen as the observation group that suffered gallstones and choledocholithiasis and were treated with peritoneoscope and choledochoscope from Aug. 2012 to Aug. 2013. Another 85 cases that were treated with open cholecystectomy during the same period were selected as the control group. The two groups were observed in terms of surgeries, complications, and changes of the serum CRP. Results The observation group was enormously lower than the control group in terms of blood losses during the surgery, the time of flatus, hospitalization duration, and the occurrence of complications after the surgery(P <0.05). Subsequent to the treatment, the observation group was also drastically lower than the control group in the 1d, 3d, 5d serum CRP. Conclusions The proposed approach to gallstones and choledocholithiasis is both effective and safe.