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目的探讨多原发癌(multiple primary carcinoma,MPC)发病的遗传学因素。方法总结22例多MPC的临床特点,结合文献复习MPC发生的遗传学基础。结果本组经病理证实的MPC22例,其中男性14例,女性8例。有家族史8例,占36.4%。首发癌前3位为结直肠癌6例,胃癌4例,乳腺癌4例;第二原发癌前3位为结直肠癌7例,肺癌5例,食管癌3例。同时性癌5例,异时性癌17例。第一和二原发癌发生相距中位时间38月(0～116月)。符合文献报道范畴和当地肿瘤疾病谱。结论鉴于MPC发病的遗传学因素,对有明显家族史的癌症患者,随访时要特别注意MPC的发生。
Objective To investigate the genetics of multiple primary carcinoma (MPC). Methods The clinical features of 22 cases of multi-MPC were summarized, and the literature reviewed the genetics of MPC. Results The group of pathologically confirmed 22 cases of MPC, including 14 males and 8 females. Family history in 8 cases, accounting for 36.4%. The first three cancers were colorectal cancer in 6 cases, gastric cancer in 4 cases and breast cancer in 4 cases. The second primary cancer in 3 cases was colorectal cancer in 7 cases, lung cancer in 5 cases and esophageal cancer in 3 cases. At the same time, 5 cases of cancer, 17 cases of metachronous cancer. The first and second primary cancers occurred at a median time of 38 months (0 to 116 months). In line with the literature coverage and local tumor spectrum. Conclusions Given the genetic determinants of MPC, MPC should be given special attention to cancer patients with a clear family history of follow-up.