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目的:探讨彩色多普勒超声(CDFI)对乳腺癌新辅助化疗(NCT)疗效评价的临床应用价值。方法:选取2013年1月~2013年12月在我院接受新辅助化疗后行手术治疗的女性乳腺癌患者55例,以病理学评价为金标准,化疗后根据化疗效果分为有效组和无效组,利用CDFI观察患者NCT前后病灶超声指标、病灶内血流分级及阻力指数(RI)值变化。结果:55例患者中,临床触诊疗效评价符合率为36.4%,敏感度为60.7%;CDFI评价符合率为70.9%,敏感度为85.7%。CDFI检查显示,乳腺癌NCT后原发肿瘤病灶大小显著缩小,边界多清晰可见,内部回声及后方回声倾向正常。有效组NCT前后病灶内的血流类型和RI值变化有统计学意义(P<0.05),无效组NCT前后病灶内的血流类型和RI值无明显变化(P>0.05)。结论:CDFI技术可对乳腺癌NCT前后病灶大小及病灶内部血流动力学变化提供客观参数,是评价乳腺癌NCT疗效的有效方法。
Objective: To investigate the clinical value of color Doppler ultrasound (CDFI) in evaluating the efficacy of neoadjuvant chemotherapy (NCT) in breast cancer. Methods: From January 2013 to December 2013 in our hospital received neoadjuvant chemotherapy after surgical treatment of 55 cases of female breast cancer, the pathological evaluation of the gold standard, according to chemotherapy after chemotherapy were divided into effective group and ineffective Group, using CDFI before and after treatment of patients with ultrasound NCT lesions, intrahepatic flow classification and resistance index (RI) changes. Results: Among the 55 patients, the coincidence rate of clinical palpation evaluation was 36.4% and the sensitivity was 60.7%. The coincidence rate of CDFI was 70.9% and the sensitivity was 85.7%. CDFI examination showed that the size of the primary tumor lesion in NCT after breast cancer was significantly reduced, the boundaries were clearly visible, and the internal echo and posterior echo tended to be normal. The changes of blood flow type and RI value in the effective group before and after NCT had statistical significance (P <0.05), but there was no significant change (P> 0.05) in the type and RI of the blood flow before and after the NCT in the invalid group. Conclusion: The CDFI technique can provide objective parameters for the size of breast lesions before and after NCT and the hemodynamic changes of the lesions. It is an effective method to evaluate the efficacy of breast cancer NCT.