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正常人肺功能有昼夜变化,大约在下午4时肺功能最佳,凌晨4时最差.哮喘患者的肺功能、下呼吸道阻力及气道反应性也有昼夜变化.夜间加重的机理是多因素和相互影响的,至今尚未完全阐明。夜间哮喘的治疗主要依据昼夜节律和各种药物的作用.COPD 患者睡眠时氧饱和度呈周期性明显降低,大多数发生于快动眼睡眠.夜间缺氧加重主要是由于肺泡低通气和通气/灌注比例失调所致。夜间低流量吸氧能消除极大部分氧饱和度下降。
Pulmonary function in patients with diurnal changes in normal, about 4 o’clock in the lung function best, the worst 4:00 in patients with asthma pulmonary function, lower respiratory tract resistance and airway reactivity also have diurnal changes.The mechanism of night aggravate is multifactorial and Interactions have not yet been fully elucidated. Nighttime asthma treatment is mainly based on circadian rhythms and the role of various drugs.COPD patients with periodic oxygen saturation during sleep decreased significantly, most occurred in fast eye movement sleep.Night hypoxia increased mainly due to alveolar hypoventilation and ventilation / Imbalance due to perfusion. Low-flow oxygen at night can eliminate most of the oxygen saturation decreased.