论文部分内容阅读
肺泡蛋白沉积症(PAP)为肺泡内表面活性物质聚积,其原因不明,需通过开胸或经支气管活检才能确诊.表面活性剂相关35KD 蛋白即表面活性剂阿朴蛋白A(Apoprotein-A,SP-A)是肺表面活性剂中主要磷脂糖蛋白,且对肺表面活性剂具有特异性.PAP 患者肺泡中积聚的表面活性剂富含SP-A.本文报道用SP-A 单克隆抗体测定PAP 患者痰中SP-A 浓度的意义.研究对象为3例经支气管镜活检确诊的PAP 患者,均有劳累性呼吸困难及低氧血症,并有咳嗽咯痰。于肺灌洗前收集10份不带唾液的痰液标本(0.5～
Pulmonary alveolar proteinosis (PAP) is the accumulation of alveolar endothelium and its cause is unknown and can only be confirmed by thoracotomy or bronchial biopsy.Apoprotein-A (SP), a surfactant related 35 kD protein, -A) is a major phospholipid glycoprotein in pulmonary surfactant and is specific for pulmonary surfactant.The surfactant accumulated in the alveoli in patients with PAP is enriched with SP-A.It is reported here that the activity of PAP with SP-A monoclonal antibody The significance of SP-A concentration in sputum of patients.The subjects were 3 PAP patients diagnosed by bronchoscopy biopsy, both had exertional dyspnea and hypoxemia and had cough and expectoration. Before lung lavage collected 10 samples of sputum without saliva (0.5 ~