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链激酶是基因工程重组的一种新的生物制剂,临床用于治疗血栓性疾病。材料与方法 一、基因工程重组链激酶为白色粉末状,易溶于水,由山东金泰生物工程公司提供。 二、实验动物为昆明种小白鼠,体重为25～30克。 三,按传统致畸试验方法,孕鼠75只随机分为5组,3组给予链激酶,剂量各为LD_(50)的1/5、1/25、1/50即16、3.2、1.6mg/kg。另2组为阴性对照和维生
Streptokinase is a novel biologic agent for genetic engineering that is clinically used to treat thrombotic disorders. Materials and methods First, the genetic engineering recombinant streptokinase is a white powder, soluble in water, provided by Shandong Jintai Biological Engineering Company. Second, the experimental animals Kunming mice, weighing 25 to 30 grams. Third, according to the traditional method of teratogenicity test, 75 pregnant rats were randomly divided into 5 groups, 3 groups were given streptokinase, the dose of each LD_ (50) 1 / 5,1 / 25,1 / 50 that is 16,3.2,1.6 mg / kg. The other two groups were negative control and maintenance