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克拉维酸(Clavulanic acid)是由棒状链霉菌产生的.它能抑制质粒内β-内酰胺酶活性.基于此,作者用含克拉维酸血浆与青霉素酶混合,以抑制青霉素酶的活性,然后再加入青霉素G,分光光度法测定残留青霉素含量,实测用青霉素自动分析仪检测.生物利用度和药物动力学观察是在8名健康志愿者中进行.志愿者男性年龄为22～51岁,药前禁食过夜,第二天分别口服或静注克拉维酸钾盐溶液,体积限制在300ml以
Clavulanic acid, which is produced by Streptomyces cibatus, inhibits the intracellular β-lactamase activity, on the basis of which the authors used a mixture of clavulanic acid and penicillinase to inhibit the activity of the penicillinase and then Then add penicillin G spectrophotometric determination of residual penicillin content was measured with a penicillin automatic analyzer bioavailability and pharmacokinetic observations were conducted in eight healthy volunteers.The volunteers male aged 22 to 51 years old, Before fasting overnight, the next day were oral or intravenous clavulanic acid potassium salt solution, the volume limit of 300ml to