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目的 通过研究胃肠激素与消化间期移行性复合运动(MMC)的关系,探讨 MMC发生及其调节机制。方法 应用胃十二指肠测压技术对30例健康志愿者的消化间期胃十二指肠运动的特征进行研究,并在检测过程中分别于MMCⅠ、Ⅱ和Ⅲ相采集静脉血行胃动素(MTL)、生长抑素(SS)、P物质(SP)及一氧化氮(NO)的血浆浓度检测。结果 MMC周期为112.7 min±37.2 min,MMCⅠ相最长,Ⅱ相次之、Ⅲ相最短,MMCⅢ相多起源于胃窦,也可起源于十二指肠。MMC多向远端移行,偶见逆向传导。MMCⅢ相血浆MTL为921.7 pg/ml±109.8 pg/ml,SP为10.9 pg/ml±7.2 pg/ml,明显多于Ⅰ相(分别为334.7 pg/ml±58.1 pg/ml,11.3 pg/ml±8.8 pg/ml)和Ⅱ相(分别为 370.0 pg/ml±69.2 pg/ml,11.0 pg/ml±10.0 pg/ml),差异有统计学意义(P<0.05)。血浆 SS、NO水平各时相相比差异无统计学意义(P>0.05)。结论 MTL、SP可能与 MMCⅢ相的诱发有关。血浆 SS、NO水平可能对胃肠MMC无直接作用。
OBJECTIVE: To investigate the mechanism of MMC and its regulation by studying the relationship between gastrointestinal hormones and interdynamic transitional cell motility (MMC). Methods Gastroduodenal pressure-measuring technique was used to study the gastrointestinal gastroduodenal motility in 30 healthy volunteers. During the test, venous hemotoxins were collected from MMC Ⅰ, Ⅱ and Ⅲ respectively. (MTL), somatostatin (SS), substance P (SP) and nitric oxide (NO) in plasma were measured. Results The duration of MMC was 112.7 min ± 37.2 min. The MMC Ⅰ phase was the longest, the Ⅱ phase was the second, and the phase Ⅲ was the shortest. The MMC Ⅲ phase originated from the gastric antrum and originated from the duodenum. MMC migration to more remote, occasionally reverse conduction. The MMC III phase plasma MTL was 921.7 pg / ml ± 109.8 pg / ml with a SP of 10.9 pg / ml ± 7.2 pg / ml, significantly more than the phase I (334.7 pg / ml ± 58.1 pg / ml, 11.3 pg / ml ± 8.8 pg / ml) and phase II (370.0 pg / ml ± 69.2 pg / ml and 11.0 pg / ml ± 10.0 pg / ml, respectively). The difference was statistically significant (P <0.05). Plasma SS, NO levels in each phase was no significant difference (P> 0.05). Conclusion MTL and SP may be related to the induction of MMC Ⅲ phase. Plasma SS, NO levels may have no direct effect on gastrointestinal MMC.