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研究发现,吗啡等外源性阿片样物质主要是通过μ受体产生镇痛作用,而。受体在阿片镇痛中的作用尚不清楚。作者等用脑片膜片箝技术和行为学实验相结合的方法研究了μ与к受体在中缝大核(NRM)中对病调节相互作用的可能机制。结果表明:(1)在NRM中,к与μ受体分别存在于两种
The study found that morphine and other exogenous opioid analgesic effect by μ receptors. The role of receptors in opiate analgesia is unclear. The authors used a combination of brain patch clamp techniques and behavioral experiments to investigate the possible mechanisms by which μ and к receptors interact with the disease in the enlarged mesenchyme (NRM). The results show that: (1) In NRM, к and μ receptors exist in two kinds respectively