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目的 评价国产注射用阿齐霉素对呼吸、泌尿系统急性细菌性感染的疗效及安全性。方法 40例病人分为阿齐霉素治疗组 15例、红霉素对照组 15例和开放组 (阿齐霉素 ) 10例。给药方法为阿齐霉素 0 5 g,每天 1次 ,静脉滴注 ;乳糖酸红霉素 0 5 g,每天 2次 ,静滴 ;疗程均为5天～ 7天。结果 阿齐霉素治疗总的临床有效率为 96% ( 2 4 2 5 ) ,呼吸系统感染随机对照研究显示阿齐霉素的临床疗效明显优于乳糖酸红霉素 (有效率分别为 93%和 5 3% ,P<0 0 5 ) ,细菌清除率也明显高于后者 (分别为 10 0 %和 60 % ,P<0 0 5 )。治疗组不良反应发生率明显低于对照组(分别为 12 %和 40 % ,P<0 0 5 )。结论 国产注射用阿齐霉素对呼吸、泌尿系统的急性细菌性感染有效而安全。
Objective To evaluate the efficacy and safety of domestic azithromycin for acute bacterial infections of respiratory and urinary system. Methods 40 patients were divided into azithromycin treatment group 15 cases, erythromycin control group 15 cases and open group (azithromycin) 10 cases. Methods of administration of azithromycin 0 5 g, 1 times a day, intravenous infusion; erythromycin lactobionate 0 5 g, 2 times a day, intravenous infusion; course of treatment were 5 days to 7 days. Results The total clinical effective rate of azithromycin was 96% (2452). The randomized controlled trials of respiratory infection showed that the clinical efficacy of azithromycin was significantly better than that of erythromycin lactobionate (effective rates were 93% And 53%, respectively, P <0 05), and the bacterial clearance rate was also significantly higher than the latter (10 0% and 60% respectively, P 0 05). The incidence of adverse reactions in the treatment group was significantly lower than that in the control group (12% and 40%, P <0 05). Conclusion Domestic injection of azithromycin is effective and safe for acute bacterial infections of respiratory and urinary system.