ARDS 的发病机理较为复杂,不同病因在发病机理中的作用不尽一致。但其基本病变是肺毛细血管广泛性损伤所致的急性肺微循环障碍。ARDS 急性肺微循环障碍主要为肺毛细血管内皮损伤,血小板及白细胞的聚集,微血栓形成,微血管痉挛收缩,血管通透性增加以致间质及肺泡性水肿、出血、肺泡萎陷。一、急性肺微循环障碍的发病机理 The pathogenesis of ARDS is more complicated, the role of different causes in the pathogenesis are not the same. However, its basic lesion is an acute pulmonary microcirculation disorder caused by extensive damage of pulmonary capillaries. ARDS acute pulmonary microcirculation disorders are mainly pulmonary capillary endothelial damage, platelet and leukocyte aggregation, micro-thrombosis, microvascular spasm contraction, increased vascular permeability and interstitial and alveolar edema, bleeding, alveolar collapse. First, the pathogenesis of acute pulmonary microcirculation disorders