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目的研究新型抗癫药物拉莫三嗪(LTG)和传统抗癫药物卡马西平(CBZ)对新诊断部分发作性癫患者认知功能和生活质量的影响。方法采用随机、对照的临床研究方法,将符合标准的50例癫患者进行一组神经心理学和癫患者生活质量量表31(QOLIE31),以及头颅CT/MR、脑电图等检查,之后随机分别给予CBZ和LTG治疗。12周后复查相同检查。结果CBZ组治疗后较治疗前:逻辑延迟记忆下降,数字符号减少,QOLIE31中综合QOL和总体健康水平得分增加((P<0.05或0.01)),但药物影响和认知功能得分均下降(P<0.01);LTG组治疗后较治疗前:A型、B型连线测验时间、stroop读色时间减少,逻辑记忆、逻辑延迟记忆、计算力以及数字符号增加(P<0.05或0.01),QOLIE31中情绪、总体健康水平、精力/疲乏、社会功能得分增加(P<0.05或0.01),药物影响得分下降(P<0.01),认知功能得分无显著性差异(P>0.05)。CBZ与LTG组治疗前后差值比较:LTG组A型连线时间减少(P<0.01),stroop读字正确数、逻辑延迟记忆、数字符号增加(P<0.05或0.01),LTG在药物影响和认知功能得分均优于CBZ组(P<0.01)。结论LTG在一定程度上可以改善新诊断部分发作性癫患者认知功能和生活质量。目的研究新型抗癫药物拉莫三嗪(LTG)和传统抗癫药物卡马西平(CBZ)对新诊断部分发作性癫患者认知功能和生活质量的影响。方法采用随机、对照的临床研究方法,将符合标准的50例癫患者进行一组神经心理学和癫患者生活质量量表31(QOLIE31),以及头颅CT/MR、脑电图等检查,之后随机分别给予CBZ和LTG治疗。12周后复查相同检查。结果CBZ组治疗后较治疗前:逻辑延迟记忆下降,数字符号减少,QOLIE31中综合QOL和总体健康水平得分增加((P<0.05或0.01)),但药物影响和认知功能得分均下降(P<0.01);LTG组治疗后较治疗前:A型、B型连线测验时间、stroop读色时间减少,逻辑记忆、逻辑延迟记忆、计算力以及数字符号增加(P<0.05或0.01),QOLIE31中情绪、总体健康水平、精力/疲乏、社会功能得分增加(P<0.05或0.01),药物影响得分下降(P<0.01),认知功能得分无显著性差异(P>0.05)。CBZ与LTG组治疗前后差值比较:LTG组A型连线时间减少(P<0.01),stroop读字正确数、逻辑延迟记忆、数字符号增加(P<0.05或0.01),LTG在药物影响和认知功能得分均优于CBZ组(P<0.01)。结论LTG在一定程度上可以改善新诊断部分发作性癫患者认知功能和生活质量。
Objective To investigate the effects of the new antiepileptic drug lamotrigine (LTG) and traditional antiepileptic drug carbamazepine (CBZ) on the cognitive function and quality of life in newly diagnosed seizure patients. Methods Fifty patients with epilepsy were enrolled in a randomized, controlled clinical study. Neuropsychological and epileptic quality of life questionnaire 31 (QOLIE31), cranial CT / MR, electroencephalogram and other tests were performed. Randomized CBZ and LTG treatment. 12 weeks after the review of the same examination. Results Compared with before treatment, the CBZ group showed a decrease in logic delay memory and number signs, a higher overall QOL and overall health score in QOLIE31 (P <0.05 or 0.01), but a decrease in drug influence and cognitive function (P (P <0.05 or 0.01). In the LTG group, QOLIE31 (P <0.05 or 0.01) was significantly increased in the LTG group compared with that before the treatment: type A and type B connection test time, stroop color reading time, logical memory, logical delay memory, (P <0.05 or 0.01), decreased drug influence (P <0.01), and no significant difference in cognitive function scores (P> 0.05). Compared with the difference between before and after treatment in CBZ and LTG group, the connection time of type A in LTG group decreased (P <0.01), the number of stroop words read correctly, logical delay memory and number sign increased (P <0.05 or 0.01) Cognitive function scores were better than CBZ group (P <0.01). Conclusions LTG can improve the cognitive function and quality of life of newly diagnosed seizures in some extent. Objective To study the effects of new antiepileptic drugs lamotrigine (LTG) and traditional antiepileptic drug carbamazepine (CBZ) on the cognitive function and quality of life of newly diagnosed epileptic patients. Methods A randomized, controlled clinical study was conducted in 50 patients with epilepsy who met the criteria of neuropsychological and epileptic quality of life questionnaire 31 (QOLIE31), and cranial CT / MR, EEG and other tests, and then randomly Give CBZ and LTG respectively. 12 weeks after the review of the same examination. Results Compared with before treatment, the CBZ group showed a decrease in logic delay memory and number signs, a higher QOL and overall health score in QOLIE31 (P <0.05 or 0.01), but a decrease in drug influence and cognitive function (P (P <0.05 or 0.01). In the LTG group, QOLIE31 (P <0.05 or 0.01) was significantly increased in the LTG group compared with that before the treatment: type A and type B connection test time, stroop color reading time, logical memory, logical delay memory, (P <0.05 or 0.01), decreased drug influence (P <0.01), and no significant difference in cognitive function scores (P> 0.05). Compared with the difference between before and after treatment in CBZ and LTG group, the connection time of type A in LTG group decreased (P <0.01), the number of stroop words read correctly, logical delay memory and number sign increased (P <0.05 or 0.01) Cognitive function scores were better than CBZ group (P <0.01). Conclusions LTG can improve the cognitive function and quality of life of newly diagnosed seizures in some extent.