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目的:观察扶正消瘢饮调护对乳腺癌术后放化疗患者生存质量的影响。方法:将94例乳腺癌术后患者随机分为对照组和观察组各47例。对照组给予规范的放疗、化疗,并给予积极的对症支持疗法。观察组在对照组治疗的基础上,加用扶正消瘢饮内服及心理调护等手段干预,进行8周的随访。采用乳腺癌患者生存质量测定量表(QLQ-BR53)评价患者的生存质量;采用焦虑量表(SAS)和抑郁量表(SDS)评定患者心理状态。结果:治疗后,对照组躯体功能、角色功能、情绪功能、认知功能、社会功能5个功能领域及整体生活质量变化不明显,观察组上述维度评分均较治疗前升高(P<0.05,P<0.01),并高于对照组(P<0.05,P<0.01);对照组恶心呕吐、食欲丧失、失眠、便秘评分较治疗前升高(P<0.05,P<0.01),而观察组上述维度评分则下降(P<0.01),并低于对照组(P<0.01);观察组疲乏、疼痛、腹泻评分较治疗前下降(P<0.01),并低于对照组(P<0.01);2组治疗后经济困难评分较治疗前上升(P<0.05),但组间比较,差异无显著性意义(P>0.05),2组体型和未来看法评分均治疗前升高(P<0.05,P<0.01),观察组未来看法的评分高于对照组(P<0.01);2组性功能、性乐趣、乳房症状评分均较治疗前下降(P<0.05,P<0.01),观察组下降更为显著(P<0.01);2组系统疗法副作用和脱发引起的烦恼评分较治疗前升高(P<0.01),对照组上升更为明显(P<0.01)。2组SAS和SDS量表评分均较治疗前下降(P<0.01),观察组SAS和SDS量表评分均低于对照组(P<0.01)。结论:扶正消瘢饮结合心理调护手段改善了患者的焦虑和抑郁情绪,减轻了放化疗所致毒副反应,改善了临床症状,提高了乳腺癌术后放化疗患者的生存质量,值得临床使用。
Objective: To observe the effect of Fuzheng Xiaoyu Decoction on the quality of life of patients with postoperative radiotherapy and chemotherapy of breast cancer. Methods: 94 cases of postoperative breast cancer patients were randomly divided into control group and observation group, 47 cases each. Control group given standard radiotherapy and chemotherapy, and give positive symptomatic and supportive therapy. On the basis of the treatment of the control group, the observation group was given the intervention of Fuzheng Xiaoyu Decoction, psychological intervention and so on for 8 weeks. The quality of life of the patients was assessed by Quality of Life Scale (QLQ-BR53). The anxiety scale (SAS) and depression scale (SDS) were used to evaluate the psychological status of the patients. Results: After treatment, there were no significant changes in the five functional domains and the overall quality of life of the control group in terms of somatic function, role function, emotional function, cognitive function and social function. The scores of the above dimensions in the observation group were significantly higher than those before treatment (P <0.05, (P <0.01), and higher than the control group (P <0.05, P <0.01). The scores of nausea and vomiting, loss of appetite, insomnia and constipation in the control group were significantly higher than those before treatment (P <0.05, P <0.01) The scores of the above dimensions decreased (P <0.01) and were lower than those of the control group (P <0.01). The scores of fatigue, pain and diarrhea in the observation group were significantly lower than those in the control group (P <0.01) (P <0.05). However, there was no significant difference between the two groups (P> 0.05), and the score of body shape and future opinion of two groups increased before treatment (P <0.05 , P <0.01). The score of the future opinion of the observation group was higher than that of the control group (P <0.01). The scores of sexual function, sexual pleasure and breast symptom in the two groups were lower than those before treatment (P <0.05, P <0.01) (P <0.01). The adverse reactions caused by side effects of systemic therapies and hair loss were higher than those before treatment (P <0.01), and those in the control group increased more significantly (P <0.01). The scores of SAS and SDS in two groups were lower than those before treatment (P <0.01). The scores of SAS and SDS in observation group were lower than those in control group (P <0.01). Conclusion: Fuzheng Xiao scar drink combined with psychological means to improve the patient’s anxiety and depression, reduce the side effects caused by radiotherapy and chemotherapy, improve the clinical symptoms and improve the quality of life of patients with postoperative chemoradiotherapy of breast cancer, deserved clinical use .