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目的:观察灵仙新苷(AR)的镇痛、抗炎作用。方法:通过扭体法和热板法致小鼠实验性疼痛模型,观察AR的镇痛作用;采用二甲苯致小鼠耳廓肿胀模型观察该药的非特异性抗炎作用;通过大鼠足跖皮内注射Freunds完全佐剂模型观察该药对大鼠佐剂性关节炎的继发病变的影响。结果:AR高、中、低剂量组、阿司匹林组和白芍总苷组可显著减少醋酸所致疼痛小鼠的扭体次数;其中AR高、中剂量组和阿司匹林组可显著延长疼痛小鼠扭体潜伏期。吗啡组、AR高、中、低剂量组以及白芍总苷组于给药后可不同程度提高热板模型小鼠的痛阈值。AR各组以及阿司匹林和白芍总苷组皆可显著抑制由二甲苯引起的小鼠耳肿胀。AR高、中、低各剂量组以及阿司匹林和白芍总苷组可显著抑制棉球所致肉芽组织的增生。AR高、中、低剂量组以及环磷酰胺和白芍总苷对弗氏佐剂引起的大鼠免疫性炎症的继发病变有显著治疗作用。结论:AR有较强的抗炎镇痛作用,并呈现一定的剂量相关性。
Objective: To observe the analgesic and anti-inflammatory effects of Lingxinxin (AR). METHODS: The experimental pain model in mice was induced by the writhing method and hot plate method. The analgesic effect of AR was observed. The non-specific anti-inflammatory effect of the drug was observed by the mouse ear swelling model induced by xylene. The Freunds complete adjuvant model was injected intradermally to observe the effect of this drug on secondary lesions of adjuvant arthritis in rats. RESULTS: AR high, middle and low dose groups, aspirin group and total glucosides of paeony could significantly reduce the number of writhing of pain mice induced by acetic acid; AR high, middle dose group and aspirin group could prolong the pain significantly. Body latency. The morphine group, AR high, middle and low dose groups and total glucosides of paeony could increase the pain threshold of hot plate model mice after administration. Both groups of AR and aspirin and total glucosides of paeony significantly inhibited ear swelling of mice caused by xylene. AR high, middle and low dose groups and aspirin and total glucosides of paeony could significantly inhibit the proliferation of granulation tissue caused by cotton balls. AR high, medium and low dose groups as well as cyclophosphamide and total glucosides of paeony had significant therapeutic effects on Freud’s adjuvant secondary lesions of rat’s immune inflammation. Conclusion: AR has strong anti-inflammatory and analgesic effects, and presents a dose-related relationship.