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泊洛沙姆108(Poloxamer 108)为制药用新型辅料。小白鼠灌胃LD_(50)>30g/kg;静脉注射LD_(50)为6.56±0.31g/kg;腹腔注射LD_(50)为6.68±0.38g/kg.亚急性毒性表明正常犬静脉注射0.05g/kg和0.15g/kg连续4周对血象、血脂、肾功能均无影响。低剂量对部分肝细胞有极轻微浊肿,大剂量组部分细胞浊肿增强。本品在红细胞混悬液中10%浓度不溶血。腹腔注射本品2g/kg对小鼠自发活动及皮下注射2g/kg对小鼠戊巴比妥钠催眠作用均无影响。0.4g/kg对犬呼吸、血压、心电图及家兔颈总动脉血流量均无明显影响。对家兔阴道粘膜和皮肤无刺激性。
Poloxamer 108 is a new excipient for pharmaceuticals. The mice were given intragastric administration of LD_(50)>30g/kg; intravenous LD_(50) was 6.56±0.31g/kg; intraperitoneal injection of LD_(50) was 6.68±0.38g/kg. Subacute toxicity showed that normal dogs were injected intravenously 0.05 G/kg and 0.15 g/kg for 4 consecutive weeks had no effect on hemogram, blood lipid and renal function. Low doses showed very slight edema in some hepatocytes, and some cells in the high dose group had increased turbid swelling. This product is not hemolyzed at 10% concentration in red blood cell suspension. Intraperitoneal injection of the product 2g/kg spontaneous activity of mice and subcutaneous injection of 2g/kg had no effect on the hypnotic effect of mice sodium pentobarbital. 0.4g/kg had no significant effect on respiration, blood pressure, electrocardiogram, and blood flow of common carotid artery in rabbits. No irritation to rabbit vaginal mucosa and skin.