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女性张力性尿失禁是由于尿道阻力降低所致。尿道总阻力的33%是由尿道粘膜因素构成。尿道粘膜增生及厚度增加均可增加尿道阻力。绝径妇女尿道粘膜萎缩降低尿道阻力而产生张力性尿失禁。女性尿道及阴道的远端均起源于胎儿的尿生殖窦,女性尿道含高浓度的雌激素受体。尿道及膀胱三角区的雌激素受体含量与阴道相似。因此,给予雌激素后可望尿道产生与阴道相似的雌激素效应。对10例经临床及尿路动力学检查确诊真性张力性尿失禁的绝经妇女进行研究。在给予雌激素阴道霜治疗前及治疗后6周分别对患者进行临床评估并经尿道镜取尿道中段细胞进行细胞学检查。
Female urinary incontinence is due to decreased urethral resistance. 33% of the total urethral resistance is composed of urethral mucosal factors. Urethral mucosal hyperplasia and increased thickness can increase urethral resistance. Diabetic women urethral mucosa atrophy reduce urethral resistance and tension incontinence. Female urethra and vagina distal originated in the fetal urogenital sinus, female urethra with high concentrations of estrogen receptors. Urinary tract and bladder trigone estrogen receptor content and vaginal similar. Therefore, given the estrogen is expected to produce urethra and vaginal similar estrogen effect. Ten cases of menopausal women diagnosed with true tension urinary incontinence by clinical and urodynamic studies were studied. Before estrogen vaginal cream treatment and 6 weeks after treatment, the patients were evaluated clinically and the urethral middle cells were taken for cytological examination.