自体免疫性溶血性贫血是溃疡性结肠炎的一种少见的并发症,但存在时则可能危及生命。作者报告3例都经治疗成功。文献报导中,红细胞异常,包括轻度溶血,常发生于用柳氮磺胺吡啶(Sulfasalazine)的溃疡性结肠炎患者,但也有作者认为后者发生自体免疫性溶血性贫血与柳氮磺胺吡啶显然无关。由于溃疡性结肠炎患者有预先存在的自体免疫性疾患,故它与抗人球蛋白(Coombs氏)试验阳性的溶血性贫血有关,并不是令人惊奇的。虽然无溶血而仅有Coombs氏试验阳性者只需继续观察,但严重的溶血则是一个重要的临床问题。作者复习了文献中16例严重自体免疫性溶血性贫血伴有溃疡性结肠炎的患者。13例患者中的4例对皮质类固醇激素有满意疗效,而其他病例疗效则较差。这4例中,1例在发生溶血之前11年曾作全结肠切除 Autoimmune hemolytic anemia is a rare complication of ulcerative colitis, but it can be life-threatening if present. The authors report 3 cases were successfully treated. Reported in the literature, abnormal erythrocytes, including mild hemolysis, often occur in patients with ulcerative colitis with sulfasalazine, but there are also some authors believe that the latter autoimmune hemolytic anemia is obviously not related to sulfasalazine . Since ulcerative colitis patients have a preexisting autoimmune condition, it is not surprising that it is associated with hemolytic anemia positive for the Coombs test. Although only hemolysis without Coombs test positive only need to continue to observe, but severe hemolysis is an important clinical problem. The authors reviewed 16 patients with severe autoimmune hemolytic anemia associated with ulcerative colitis in the literature. Four of the 13 patients had a satisfactory response to corticosteroids, while others were less effective. Of the 4 cases, 1 had total colon resection 11 years prior to hemolysis