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用特异性DNA 片断标记法(TUNEL) 研究了25例皮肤鳞状细胞癌(SCC) ,同时观察了Bax 和Bcl2 基因的表达。结果19 例发现凋亡细胞,6 例Bcl2 弱阳性染色, 全部病例Bax 染色阳性, 调亡均数与Bax 强度显著正相关,推测SCC 发生的原因不是由于细胞凋亡受到抑制。
Twenty-five cases of cutaneous squamous cell carcinoma (SCC) were studied using specific DNA fragment labeling (TUNEL). The expression of Bax and Bcl-2 genes was also observed. Results Apoptotic cells were found in 19 cases, and 6 cases were weakly stained with Bcl-2. All cases were positive for Bax staining, and the mean number of apoptosis was positively correlated with Bax intensity. It was speculated that the cause of SCC was not due to inhibition of apoptosis.