论文部分内容阅读
目的探讨高水平纤维蛋白原(FIB)对糖尿病患者冠状动脉病变严重程度的影响。方法对216例疑诊为冠心病的患者进行冠状动脉造影,图像分析后根据冠状动脉损害程度评分。①根据有无糖尿病以及冠状动脉造影情况分为3组:正常对照组51例,无糖尿病的冠心病组103例和有糖尿病的冠心病组62例,比较3组FIB水平。②在有无糖尿病及FIB水平分4级的基础上,对糖尿病组和非糖尿病组男、女性别分亚组比较冠状动脉狭窄程度。均检测FIB、总胆固醇、甘油三酯、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇、D-二聚体。结果3组间的冠状动脉病变程度和FIB水平比较,差异均有统计学意义(均P<0.05)。多元逐步回归分析显示:糖尿病、FIB、年龄和性别是影响冠状动脉病变程度的重要变量(F值分别为24.13、19.33、18.42、15.92,均p<0.10;复相关系数为0.32、0.40、0.46、0.49,均p<0.01)。冠状动脉病变程度随着FIB的升高而加重,糖尿病患者在相同的FIB水平上较非糖尿病患者冠状动脉病变明显加重,其中男性较女性更为明显。结论高水平的FIB可以反映冠状动脉病变的严重程度,而男性患者较女性更为明显。
Objective To investigate the effect of high level fibrinogen (FIB) on the severity of coronary artery disease in diabetic patients. Methods Totally 216 patients with suspected coronary heart disease underwent coronary angiography. The images were analyzed according to the degree of coronary artery injury. ①According to the presence or absence of diabetes and coronary angiography, the patients were divided into three groups: 51 cases of normal control group, 103 cases of non-diabetic coronary heart disease group and 62 cases of coronary heart disease group with diabetes mellitus. FIB levels were compared between the three groups. ② In the presence of diabetes and FIB levels on a 4-level basis, the degree of coronary artery stenosis was compared between men and women in the diabetic and non-diabetic groups. FIB, total cholesterol, triglycerides, low density lipoprotein cholesterol and high density lipoprotein cholesterol, D-dimer were all detected. Results There were significant differences in the degree of coronary artery lesion and FIB between the three groups (all P <0.05). Multivariate stepwise regression analysis showed that diabetes, FIB, age and sex were the important variables influencing the severity of coronary artery disease (F = 24.13, 19.33, 18.42 and 15.92 respectively, all p <0.10; the correlation coefficients were 0.32, 0.40 and 0.46, 0.49, all p <0.01). The degree of coronary artery disease increased with the increase of FIB. Diabetic patients at the same level of FIB were significantly worse than non-diabetic patients with coronary artery disease, in which males were more obvious than females. Conclusion The high level of FIB can reflect the severity of coronary artery disease, while the male patients are more obvious than the female.