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本文阐述了心血管疾病表观遗传机制研究的最新进展,包括与动脉粥样硬化及外环境变化引起的血管平滑肌细胞和心肌细胞表型可塑性改变有关的DNA甲基化、组蛋白修饰和染色体重塑等表观遗传变化,以及其应用于心血管疾病治疗的前景。
This article describes the recent advances in the study of the epigenetic mechanisms of cardiovascular disease, including DNA methylation, histone modification, and chromosomal weight associated with changes in phenotypic plasticity of vascular smooth muscle cells and cardiomyocytes caused by changes in atherosclerosis and external environment Plastic and other epigenetic changes, and its application in the treatment of cardiovascular disease prospects.