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为了寻找用于小儿发热迅速退热的药物,作者分别用布洛芬栓剂(每栓含布洛芬50mg)与羟基保太松栓剂(每栓含羟基保太松100mg),以双盲法进行退热效果的对比观察。结果:(1)退热作用,布洛芬组的有效率为89.7%,而羟基保太松组的有效率为65.4%。(2)从经时平均体温变化观察,布洛芬组具有快速的退热效果,且能维持其退热作用,与羟基保太松组比较,统计学上有明显差异。(3)两组中无一例产生副作用。出现体温过度下降的有3例(占2.8%),但不必治疗不久能恢复正常。也未见布洛芬栓剂对直肠粘膜产生不良影响。临床结果表明,布洛芬栓剂作为小儿解热药物疗效确切
In order to find a rapid fever for pediatric fever drugs, the authors were ibuprofen suppository (each containing ibuprofen 50mg) and hydroxy paeonycholine suppository (each containing penehyclidine 100mg), respectively, by double-blind method Comparison of antipyretic effect. Results: (1) The antipyretic effect was 89.7% in the ibuprofen group and 65.4% in the hydroxybutyl acetate group. (2) From the observation of the change of mean body temperature over time, the ibuprofen group has a rapid antipyretic effect, and can maintain its antipyretic effect. Compared with the hydroxyparaben group, there is a statistically significant difference. (3) None of the two groups had side effects. Three patients (2.8%) experienced hypothermia, but did not have to return to normal soon after treatment. Nor did ibuprofen suppositories have a negative effect on the rectal mucosa. Clinical results show that, Ibuprofen suppository as pediatric antipyretic drugs curative effect