药物载体中以脂质体对组织细胞的毒性低并可被生物降解.因此作为抗肿瘤药物如抗生素、激素、蛋白和DNA等的载体而受到了极大的重视。本文讨论了脂质体各种给药途径的分布特点及其与化疗的关系。一、脂质体的静脉注射脂质体静脉注射给药后,迅速从血循环中消除,其清除率与脂质体的大小及其表面所带电荷有关。小的脂质体比大的消除慢。在血液循环中,脂质体的某些性质如渗透性、粒径大小、表面电荷等迅速被改变并破坏其完整性。增加卵磷脂脂质体中胆固醇的含量,可以减少包封物的渗漏。同样,在卵磷脂中掺入神经鞘磷脂和神经节苷脂可以增加循环中脂质体的稳定性 Liposomes are low toxicity and can be biodegraded by liposomes in drug carriers, so they have drawn great attention as carriers of antitumor drugs such as antibiotics, hormones, proteins and DNA. This article discusses the distribution of various routes of administration of liposomes and their relationship with chemotherapy. First, the liposomes intravenous injection of liposomes intravenous administration, the rapid elimination from the blood circulation, the clearance rate and the size of the liposomes and the charge on its surface. Small liposomes are slower than larger ones. In the blood circulation, certain properties of the liposomes such as permeability, particle size, surface charge and the like are quickly changed and their integrity is destroyed. Increasing cholesterol levels in lecithin liposomes can reduce encapsulation leakage. Likewise, the incorporation of sphingomyelin and gangliosides in lecithin increases the stability of liposomes in the circulation