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用食管癌高发区林县任村公社井头大队旱井水进行Wistar大鼠诱癌实验,并测定了其中的NO_3~-、NO_2~-,二级胺和氨氮含量,探讨饮用水与食管癌的关系。结果,第1组(喂饲浓缩10倍旱井水的大鼠):前胃乳头状瘤和肝癌的发生率分别为11.1％(4/36)和2.8％(1/36)。第2组(喂饲0.1％肌氨酸乙酯旱井水溶液的大鼠):前胃乳头状瘤和早期癌的发生率为36.4％(4/11)和18.2％(2/11);食管乳头状瘤仅发生1/11例,占9.1％。第3组(喂饲0.1％甲基苄胺旱井水溶液的大鼠):前胃乳头状瘤和早期癌发生率为10.5％(2/19)和5.3％(1/19);食管乳头状瘤和食管早期癌发生率分别为15.9％(3/19)和5.3％(1/19)。第4组(喂饲0.1％二乙胺旱井水溶液的大鼠),34例中仅见到1例前胃瘤前病变(2.9％)。第5组(喂饲旱井水加黑曲霉霉食的大鼠)诱发了前胃乳头状瘤(23.5％,4/17)和早期癌(5.9％,1/19)。对照组动物14只,未见到上述病变。实验期间,于春、夏、冬三季还测定了旱井水中的NO_3、NO_2~-氨氮和二级胺氮含量,前三者含量均不高于一般饮用水标准。
Wistar rats were induced by the wellhead water in the wellhead battalion of Rencun community in Linxian County, a high-risk area of esophageal cancer, and the levels of NO_3~-, NO_2~-, secondary amines and ammonia nitrogen were measured to investigate drinking water and esophageal cancer. Relationship. As a result, the incidence of pro-stomach papilloma and hepatocellular carcinoma was 11.1% (4/36) and 2.8% (1/36) in the first group (rats fed 10 times more concentrated well water). Group 2 (Rat rats fed 0.1% sarcosine ethyl aqueduct solution): The incidence of progastric papilloma and early cancer was 36.4% (4/11) and 18.2% (2/11); esophagus Only 1/11 cases of papilloma occurred, accounting for 9.1%. Group 3 (rats fed an aqueous solution of 0.1% methylbenzylamine in dry wells): The incidence of precancerous papilloma and early cancer was 10.5% (2/19) and 5.3% (1/19); esophageal papillary The incidence of tumor and early esophageal cancer was 15.9% (3/19) and 5.3% (1/19), respectively. In group 4 (rats fed a 0.1% solution of diethylamine in dry wells), only one case of pre-precancerous lesion (2.9%) was seen in 34 cases. Group 5 (feeding dry wells plus rats fed with Aspergillus niger) induced progastric papilloma (23.5%, 4/17) and early cancer (5.9%, 1/19). Fourteen animals in the control group did not have the above-mentioned lesions. During the experiment, NO3, NO2~-ammonia nitrogen and secondary amine nitrogen were measured in the spring, summer and winter seasons. The contents of the first three were not higher than the standard for drinking water.