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目的探讨2型糖尿病(T2DM)患者血清中血浆妊娠相关蛋白A(PAPP-A)与颈动脉粥样斑块的相关性。方法采用双抗体夹心酶联免疫吸附实验检测单纯T2DM(A组,30例)、T2DM合并颈动脉斑块患者(B组,30例)及正常对照者(C组,28例)血清PAPP-A水平,同时检测肿瘤坏死因子(TNF)-α、糖化血红蛋白(HbA1c)、血脂、超敏C反应蛋白(hsCRP)。结果 A、B组血清PAPP-A水平均显著高于C组(P<0.05),B组血清PAPP-A水平明显高于A组(P<0.05)。B组血清PAPP-A与TNF-α呈正相关。结论 T2DM患者血清PAPP-A与慢性炎症有关,其与TNF-α共同参与颈动脉粥样斑块的形成。
Objective To investigate the correlation between serum level of pregnancy related protein A (PAPP-A) and carotid artery plaque in type 2 diabetes mellitus (T2DM). Methods Serum PAPP-A levels in patients with T2DM complicated with carotid plaques (group B, 30 cases) and normal controls (group C, 28 cases) were determined by double antibody sandwich enzyme-linked immunosorbent assay Tumor necrosis factor (TNF) -α, HbA1c, lipids and hsCRP were detected at the same time. Results The levels of PAPP-A in group A and group B were significantly higher than those in group C (P <0.05). The level of PAPP-A in group B was significantly higher than that in group A (P <0.05). Serum PAPP-A in group B was positively correlated with TNF-α. Conclusions Serum PAPP-A is associated with chronic inflammation in T2DM patients, which is involved in the formation of carotid artery plaque together with TNF-α.