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56例分泌生长激素的垂体腺瘤中,28例用冷冻外科、28例用显微外科治疗,随访3～8年。平均血清生长激素(GH)浓度低于10mU/L(毫单位/升)者,显微外科术后有19例(68%),而冷冻外科术后仅7例(25%)。垂体机能减退和手术并发症于冷冻外科术后较多见。如病人既往未经受过其他疗法,经蝶骨显微外科对降低生长激素分泌特别有效,而且不损害正常垂体功能。冷冻外科术后持续尿崩症3例,其中无1例GH浓度正常;显微外科术后持续尿崩症2例。其他并发症:冷冻外科术后6例(21%),3例
Among the 56 cases of pituitary adenoma secreting growth hormone, 28 cases were treated with cryosurgery and 28 cases were treated with microsurgery, followed up for 3 to 8 years. The mean serum growth hormone (GH) concentration was less than 10 mU/L (millions/liter), 19 cases (68%) after microsurgery, and only 7 cases (25%) after cryosurgery. Pituitary hypofunction and surgical complications are more common after cryosurgery. If the patient has not received other therapies before, transsphenoidal microsurgery is particularly effective in reducing growth hormone secretion without impairing normal pituitary function. Three cases of persistent diabetes insipidus were observed after cryosurgery. None of the cases had normal concentration of GH, and 2 cases had continuous diabetes insipidus after microsurgery. Other complications: 6 cases (21%) and 3 cases after cryosurgery