人对疟疾的免疫只有多年感染后才获得,且免疫是直接对红细胞期的原虫。临床有免疫的成人可以断断续续地出现低度虫血症。这种获得性的不完全的抵抗力属于伴随兔疫,常常对接种疫苗预防自然感染的现实性提出许多疑问。Mitchell(1977)报告,恒河猴接种裂殖子疫苗后产生对诺氏疟原虫的免疫力,较反复感染用药物治愈者更为有效。因之,接种疫苗与自然感染所获得的免疫机理在某些主要途径方面必不相同。 Human immunization against malaria was acquired only after years of infection, and immunization was a protozoan directly on the erythrocytic phase. Clinically immunized adults can develop intermittent hypovolemia intermittently. This acquired, incomplete resistance is associated with the epidemic of rabies and often raises many questions about the reality of vaccination against natural infection. Mitchell (1977) reported that rhesus macaque vaccination produces an immune response to Plasmodium knowles that is more effective than repeated infections with drug-cured patients. Therefore, the immunization mechanisms acquired by vaccination and natural infection are different in some major ways.