论文部分内容阅读
本研究通过~(125)I-udR标记肿瘤细胞DNA释放试验和扫描电镜,观察了SPA和SAC直接体内注射对带瘤小鼠腹腔巨噬细胞细胞毒及其超微结构和脾脏NK细胞细胞毒的影响;SPA和SAC对瘤细胞的直接毒效应。结果表明,SAC治疗后巨噬细胞明显活化,其体积可达对照组的2—3倍,表面皱褶增多、增厚,有许多粗大的伪足;SPA和SAC均能使巨噬细胞、NK细胞、细胞毒活性显著增强,与抗肿瘤效应的强弱似呈一致关系;二者无直接瘤细胞毒效应。这些结果提示,葡萄球菌A蛋白体内注射的抗肿瘤机制与其增强巨噬细胞和NK细胞活性有关,而与直接瘤细胞毒作用无关。
In this study, ~(125)I-udR-labeled tumor cell DNA release assay and scanning electron microscopy were used to observe the cytotoxicity of ultrastructural and splenic NK cell cytotoxicity in tumor-bearing mouse peritoneal macrophages by direct injection of SPA and SAC. The effect of SPA and SAC on the direct toxic effect of tumor cells. The results showed that macrophages were significantly activated after SAC treatment. The volume of these macrophages was 2-3 times higher than that of the control group. The surface folds increased and thickened. There were many large pseudopodia; both SPA and SAC were able to make macrophages and NK cells. Cellular and cytotoxic activity was significantly enhanced, and it was consistent with the strength of anti-tumor effects; neither had direct tumor cell cytotoxicity. These results suggest that the anti-tumor mechanism of staphylococci A protein injection in vivo is related to the enhancement of macrophage and NK cell activity, but not to direct cytotoxicity.