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关于IgE在蠕虫感染的保护性免疫反应中的作用历来存在不同的观点,作者在回顾了大量文献的基础上肯定了特异性IgE在抗蠕虫感染中的免疫保护作用及其重要性。认为对血吸虫重复感染的抵抗力与高水平的寄生虫特异性IgE抗体有关。并且讨论了寻找能刺激产生特异性IgE抗体的有效抗原作为疫苗的可能性。
There is a long history of differing perspectives on the role of IgE in the protective immune response to helminth infection. The reviewers have reviewed a large body of literature and confirmed the importance of immunoprotection of specific IgE in anthelmintic infections. Resistance to repeated infections of the schistosome is believed to be associated with high levels of parasitic specific IgE antibodies. And discussed the possibility of looking for an effective antigen that stimulates the production of specific IgE antibodies as a vaccine.