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本实验采用4个实验对盐酸二氢埃托啡(DHE)的精神依赖性潜力进行了较系统的评价 ,并与其他阿片类药物进行了比较。在FR1程序下 ,未接触过药物的恒河猴可学会踏板觅药并维持对DHE的自身给药行为 ,潜伏期较短。在交叉替代实验中 ,DHE与其他阿片类药物有良好的交叉耐受性。在可变比率实验中 ,最高的稳定比率值为VR100。在累进比率实验中 ,断点达到2022 ,而海洛因只有911。结果证明 ,盐酸二氢埃托啡具有很强的精神依赖性潜力 ,其精神依赖性潜力比海洛因强得多 ,且具有成瘾潜伏期较短 ,相邻两次注射间隔短等特点。虽然镇痛作用较强 ,但作为临床用药仍有很大的危险性。
In this experiment, we used four experiments to evaluate the psychic dependence potential of dihydroetorphine hydrochloride (DHE) systematically and compared with other opioids. Under the FR1 program, untreated rhesus macaques can learn pedal-seeking drugs and maintain self-administration of DHE with a short incubation period. In cross-over experiments, DHE has good cross-tolerance with other opioids. In variable ratio experiments, the highest stable ratio is VR100. In the progressive rate experiment, the breakpoint reached 2022, while heroin was only 911. The results show that dihydroetorphine hydrochloride has a strong spiritual dependence potential, its spiritual dependence potential is much stronger than heroin, and has a shorter incubation period, short injection interval between adjacent two characteristics. Although the strong analgesic effect, but as a clinical medication is still a great danger.