染色体的研究对白血病的病因、发病机制、诊断、治疗、预防和预后,提供了一定的科学依据。慢性白血病一、慢性粒细胞白血病(慢粒):ph~1染色体是慢粒的标记染色体,Rowley(1973)应用 Q 和 G 带技术确证 ph~1染色体不是缺失,而是第22号染色体长臂与第9号染色体易位[t(9;22)(q34;q11)]。近年来许多学者发现少数病例 ph~1染色体缺失的部分易位到第9号染色体以外的其它染色体上去,到目前为止,涉及的染色体计有1、2、3、4、5、6、7、8、9、10、11、12、13、14、15、16、17、19、21、22和 X 等,但还没有报道过涉及18、20和 Y 染色体,有人认为这可能是时间问题。上述慢粒中不典型的ph~1易位其发生率为6～8%,这些患者的临床表现、生存期与典型的(9;22)和易位的患者无显著 Chromosome research on the etiology, pathogenesis, diagnosis, treatment, prevention and prognosis of leukemia provides a scientific basis. Chronic leukemia 1. Chronic myelogenous leukemia (CK): ph ~ 1 chromosome is a marker of CML. Rowley (1973) applied Q and G band techniques to confirm that ph ~ 1 is not missing but chromosome 22 And chromosome 9 translocation [t (9; 22) (q34; q11)]. In recent years, many scholars have found that a few cases of chromosomal deletion of ph ~ 1 translocate to chromosomes other than chromosome 9, up to now, the chromosomes involved are 1,2,3,4,5,6,7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 19, 21, 22 and X. However, it has not been reported that the 18, 20 and Y chromosomes are involved. Some people think this may be a temporal problem. The incidence of ph1 translocation, which is typical of the CGRP, is between 6 and 8%, and the clinical presentation, survival and typical (9; 22) and translocations of these patients were not significant