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在清醒的胰瘘狗身上,发现甲—脑啡肽能抑制内源性刺激(肝餐、十二指肠酸化)和外源性激素(促胰液素、胆囊收缩素)所引起的胰腺分泌。对前者的抑制比对后者要强,同时伴有血浆免疫反应促胰液素含量的明显降低,说明甲—脑啡肽抑制胰腺的分泌至少部份是由于抑制了能刺激胰腺分泌的肠道激素的释放。甲—脑啡肽对外源性激素的抑制作用,表明它也能直接影响胰腺的外分泌部份。甲—脑啡肽对胰腺分泌的抑制作用,其机制尚不明瞭,鸦片受体拮抗剂——纳洛酮能部份阻止此作用,说明该作用有鸦片受体
In awake dogs with pancreatic fistula, it was found that alpha-enkephalin can inhibit pancreatic secretion caused by endogenous stimulation (liver meal, duodenal acidification) and exogenous hormones (secretin, cholecystokinin). Inhibition of the former is stronger than the latter, accompanied by a significant reduction of plasma immunoreactive secretin, indicating that at least in part, the inhibition of alpha-enkephalin secretion by the pancreas can inhibit the secretion of gut hormones freed. The inhibitory effect of a-enkephalin on exogenous hormones suggests that it also directly affects the exocrine portion of the pancreas. A-enkephalin on pancreatic secretion, the mechanism is unclear, opioid receptor antagonist - naloxone can partially prevent this effect, indicating that the role of opiate receptors