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目的用方剂计量学方法提取、解析《伤寒论》方剂之药对配伍关系。方法选取《伤寒论》方剂88首,统计用药频数,将频次较高药物进行相关分析、聚类分析,提取其中的药对;引入方剂计量学新立药对分析法,解析药对的配伍特性与运用情况。结果《伤寒论》88首方剂,全部用药431药次,共得不重复用药60味,其中29味频次较高者为常用药。对29味常用药进行相关分析,得378对两两药物组合,其中龙骨与牡蛎、生姜与大枣等18对药之两药间相关系数较高(r﹥0.40),可视为初选药对。对29味常用药进行聚类分析,以甄别初选药对,从中确定生姜大枣、人参半夏、黄芩黄连、麻黄杏仁、白术茯苓、栀子豆豉、龙骨牡蛎、枳实厚朴、粳米知母等9组药为《伤寒论》方剂之常用药对。解析9组药对,计算其运用频度、配合强度、离对比,以揭示其配对亲和程度及其独立性或依存性关系;分析其成对和离对运用功效,以表明其运用时机。结论《伤寒论》方剂药对为后世医家用药之典范,迄今仍被广泛使用;方剂计量学之药对分析法可以为方剂药对的研究和运用提供科学依据。
OBJECTIVE To extract and analyze the compatibility of the prescriptions of “Treatise on Febrile Diseases” prescriptions with the method of prescription metrology. Methods The 88 prescriptions of “Treatise on Febrile Diseases” were selected, the frequency of medication was calculated, the higher frequency drugs were analyzed, clustered and the drug pairs were extracted. A new method of prescription analysis was introduced to analyze the compatibility of drug pairs And the use of the situation. Results “Treatise on” 88 prescriptions, all medication 431 times, were not repeated medication 60 flavors, of which 29 flavors higher frequency of commonly used drugs. Of the 29 commonly used drugs for the correlation analysis, 378 pairs of two drug combinations, including keel and oysters, ginger and jujube 18 pairs of drugs, the correlation coefficient between the two drugs (r> 0.40), can be considered as primaries Correct. Cluster analysis of 29 commonly used drugs in order to identify the primary drug pairs, identified ginger jujube, ginseng Pinellia, Scutellaria Coptidis, ephedra almonds, Atractylodes Tuckahoe, Gardenia bean, Keel oyster, fructus aurantii, japonica rice known Mother and other 9 groups of drugs for the “Treatise on” prescription of commonly used drugs. Analyze 9 groups of drug pairs, and calculate their frequency of use, intensity of combination, and contrast to reveal the affinity of their pairings and their independence or dependence; analyze their paired and away from the use of efficacy to show the timing of its use. Conclusion The prescriptions of Treatise on Febrile Diseases are still the most widely used model for future generations of Chinese medicine. The prescription-based analytical method of prescription metrology can provide a scientific basis for the research and application of prescription drugs.