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目的分析深圳地区2003-2012年期间献血者HBV感染的流行走势情况。方法所有献血者血样均使用进口与国产酶联免疫试剂,以及血液病毒核酸检测(NAT)方法筛查HBsAg和HBV DNA,采用χ2检验进行统计分析献血者感染HBV的流行趋势。结果深圳地区2003-2012年采血量稳步增长,HBsAg阳性检出率总体呈下降趋势,HBsAg+/NAT+与HBsAg+/NAT-检出率结果相当(1.2∶1);献血者中HBsAg-/HBV DNA+阳性率呈升高趋势。不同年龄组献血者HBV感染率差异无统计学意义(P>0.05)。结论酶联免疫与NAT方法为重要的互补检测手段,能进一步确保输血安全,而隐匿性乙型肝炎病毒感染呈升高态势,应引起高度重视。
Objective To analyze the prevalence of HBV infection in blood donors in Shenzhen during 2003-2012. Methods Blood samples of all blood donors were screened for HBsAg and HBV DNA using imported and domestic enzyme-linked immunosorbent reagents and blood viral nucleic acid detection (NAT), and the prevalence of HBV infection in blood donors was statistically analyzed by χ2 test. Results The amount of blood collected in Shenzhen steadily increased from 2003 to 2012, and the positive rate of HBsAg positive was declining. The detection rate of HBsAg + / NAT + and HBsAg + / NAT- was similar (1.2:1). The positive rate of HBsAg- / HBV DNA + Rate was on the rise. There was no significant difference in HBV infection rate among different age groups (P> 0.05). Conclusions Enzyme-linked immunosorbent assay (ELISA) and NAT method are important complementary detection methods, which can further ensure the safety of blood transfusion. However, the occult hepatitis B virus infection is on the rise and should be highly valued.