论文部分内容阅读
目的探讨前列地尔对糖尿病伴脑梗死患者24 h尿蛋白及神经功能缺损的影响。方法选取2014年2月至2015年12月一汽总医院吉林大学第四医院收治的90例急性脑梗死合并2型糖尿病患者作为研究对象,采用随机数字表法将其分为观察组与对照组,各45例。对照组患者给予基础治疗,观察组在对照组基础上采用前列地尔进行治疗,比较两组患者治疗前后尿清蛋白及总清蛋白水平、美国国立卫生研究院卒中量表(NIHSS)及Bart1e I指数(BI)评分。结果治疗后,观察组患者24 h尿清蛋白水平明显低于对照组,差异有统计学意义(P<0.05);治疗后1、2周,观察组患者的NIHSS评分均明显低于对照组,BI评分均明显高于对照组,差异均有统计学意义(均P<0.05)。结论前列地尔联合常规治疗方法可以显著改善急性脑梗死合并2型糖尿病患者的24 h尿蛋白分泌水平,促进神经功能恢复。
Objective To investigate the effect of alprostadil on 24 h urinary protein and neurological impairment in patients with diabetes mellitus and cerebral infarction. Methods Totally 90 acute cerebral infarction patients with type 2 diabetes who were admitted to the Fourth Hospital of Jilin University from January 2014 to December 2015 were selected as research subjects and divided into observation group and control group by random number table method. 45 cases each. Patients in the control group were given basic treatment. The observation group was treated with alprostadil on the basis of the control group. Urinary albumin and total albumin levels were compared between the two groups before and after treatment. The NIH Stroke Scale (NIHSS) and Bart1e I Index (BI) score. Results After treatment, the 24-hour urinary albumin level in the observation group was significantly lower than that in the control group (P <0.05). At 1 and 2 weeks after treatment, the NIHSS scores in the observation group were significantly lower than those in the control group BI scores were significantly higher than the control group, the differences were statistically significant (P <0.05). Conclusions Alprostadil combined with conventional treatment can significantly improve 24 h urinary protein excretion and promote neurological recovery in patients with acute cerebral infarction and type 2 diabetes mellitus.