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本文介紹了N_2O減飽和法測定不开胸狗冠脉血流量的方法,并研究了海南島萝芙木根总碱的作用,及其对心肌糖代謝的影响。在X光透視下經靜脉插管至冠状資,从冠状动、靜脉血N_2O減飽和速率之差,計算心肌血流量,并从动、靜脉血氧、糖、乳酸及丙酮酸合量之差,計算心肌的消耗量及利用率。实驗設計采用配对法,进行t測驗个别比較,以分析除去动物个体差异及对照溶剂的影响后萝芙木碱本身的作用。 9只狗之各項正常数值平均数±标准差为:动脉平均压143±17毫米汞柱,冠状竇平均压8±3毫米汞柱,冠脉血流量88±21毫升/100克心肌/分,冠脉阻力1.7±0.4毫米汞柱/毫升/100克心肌/分,动脉血氧合量18.1±1.9容积%,冠状竇血氧含量5.6±1.1容积96,动脉血糖116±24毫克%,冠状竇血糖109±20毫克%,动脉乳酸24±7毫克%,冠状寶乳酸16±5毫克%,动脉丙酮酸1.7±0.5毫克%,冠状竇丙酮酸0.8±0.3毫克%。 靜脉注射萝芙木碱0.1毫克/公斤后,血压立即明显下降約25%,半小时后回升,冠脉血流量变化不显著,冠脉阻力有减低趋势,說明萝芙木碱降压时并不引起冠脉血流减少,冠状血管趋于扩张。心肌对氧、乳酸和丙酮酸的利用率很高,而对血糖消耗很少,說明心肌主要从糖的有氧代謝获取能量。靜脉注射萝芙木碱后,动脉血的乳酸及丙酮酸含量均显著增高,因此能增加心脏的能源供应,改善心肌的营养。萝芙木碱能加強左心室作功量,而心肌氧消耗量并未增高,故計算出心肌机械作功率从15%提高到20%。总結本文結果:萝芙木碱在扩张冠状血管、提高心肌作功率及增加心肌能源供应三方面都有一定的作用,因此对高血压心脏的代偿能力的提高是有利的。
In this paper, the method of N 2 O desaturation determination of coronary artery blood flow in non-open-chest dogs was introduced and the effect of total alkaloids of Rauwolfia root on Hainan Island and its effect on myocardial glucose metabolism was studied. The blood flow was calculated from the difference between the desaturation rate of N 2 O in coronary artery and venous blood, and the difference of arterial blood oxygen, glucose, lactate and pyruvate volume was calculated by X-ray fluoroscopy. Calculate myocardial consumption and utilization. Experimental design using paired method, the t test individual comparison, to analyze the removal of animal differences in individual and control solvent effect of rofecalid itself. The mean ± standard deviation for each of the 9 dogs was 143 ± 17 mm Hg for mean arterial pressure, 8 ± 3 mm Hg for mean coronary pressure, and 88 ± 21 ml for coronary blood flow / 100 g of myocardium per minute , Coronary artery resistance 1.7 ± 0.4 mmHg / ml / 100 g myocardial / min, arterial oxygenation volume 18.1 ± 1.9 vol%, coronary sinus oxygen content 5.6 ± 1.1 volume 96, arterial blood glucose 116 ± 24 mg%, coronary Sinus Blood Sugar 109 ± 20 mg%, Arterial Lactate 24 ± 7 mg%, Coronary Polylactic Acid 16 ± 5 mg%, Arterial Pyruvate 1.7 ± 0.5 mg%, Coronary Sinus Pyruvate 0.8 ± 0.3 mg%. After intravenous injection of rofuomycetin 0.1 mg / kg, the blood pressure decreased immediately after about 25%, half an hour after the rise, coronary blood flow changes were not significant, coronary resistance decreased, indicating that Rauvital alkali does not buck Coronary blood flow is reduced and coronary blood vessels tend to dilate. Myocardial oxygen, lactic acid and pyruvate utilization is high, while the consumption of blood glucose is very small, indicating that the main myocardial aerobic metabolism of sugar to obtain energy. After intravenous injection of ropinine, arterial blood lactic acid and pyruvate levels were significantly increased, thus increasing the energy supply of the heart, improve myocardial nutrition. Ralphoshine can enhance left ventricular work capacity, and myocardial oxygen consumption did not increase, so calculated for myocardial mechanical power from 15% to 20%. Summary results of this article: Rhoh alkali in the expansion of coronary vessels, improve myocardial power and increased myocardial energy supply in three aspects have a role, and therefore improve the compensatory capacity of hypertensive heart is beneficial.