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给ＳＤ大鼠腹腔注射氯化铝溶液６０天，研究不同剂量铝对神经行为以及各脑区神经细胞数和海马颗粒空泡变性（ＧＶＤ）的影响。穿梭箱实验和敞箱行为实验表明，按体重腹腔注射４．０ｍｇ／ｋｇ和１０．０ｍｇ／ｋｇ可使大鼠主动回避反应能力和自发活动显著下降。光镜下对ＨＥ染色的大脑顶叶、小脑和海马切片进行神经细胞计数，发现腹腔注射１０．０ｍｇ／ｋｇ可使大脑顶叶椎体层椎体细胞、海马椎体细胞数和小脑浦肯野细胞数显著减少。光镜下发现各组海马神经细胞均发生ＧＶＤ，腹腔注射４．０ｍｇ／ｋｇ和１０．０ｍｇ／ｋｇ组ＧＶＤ细胞数有明显增加；各组ＧＶＤ细胞阳性率与铝剂量有显著相关性。本结果进一步证实了铝的神经行为毒性，并提示该毒性与铝导致神经细胞数减少有关。
SD rats were injected intraperitoneally with aluminum chloride solution for 60 days to study the effects of different doses of aluminum on neurobehavioral changes and neuronal cell number and hippocampal granular degeneration (GVD) in each brain region. Shuttle box experiments and open-box experiments showed that intraperitoneal injection of 4.0 mg / kg and 10.0 mg / kg of body weight significantly reduced the spontaneous reactivity and spontaneous activity of rats. Under light microscope, neurons were counted in HE-stained parietal lobe, cerebellum and hippocampal slices. It was found that intraperitoneal injection of 10.0 mg / kg could induce vertebral parietal vertebral vertebral body vertebral body vertebral lamina, hippocampal vertebral cells and cerebellum Purkinje The number of cells is significantly reduced. GVD was observed under light microscope in all groups of hippocampal neurons, and the number of GVD cells in groups of 4.0 mg / kg and 10.0 mg / kg was significantly increased. The positive rate of GVD was significantly correlated with the dose of aluminum. This result further confirms the neurobehavioral toxicity of aluminum and suggests that this toxicity is associated with a decrease in the number of nerve cells that lead to aluminum.