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对富勒烯衍生物的生物活性研究结果表明它们可能在医药领域存在巨大的潜在应用价值．为了能了解作为药物或药物载体的Ｃ６０衍生物在生物体内的分布，用临床上用得最多的显像核素９９ｍＴｃ对Ｃ６０的一种简单水溶性衍生物Ｃ６０（ＯＨ）ｘ（Ｏ）ｙ进行标记，使用γ计数器测定标记物在小鼠体内各脏器和组织中放射性以及ＳＰＥＣＴ（单光子发射计算机断层）对注射有标记物的新西兰大白兔进行显像来确定Ｃ６０衍生物在生物体内的分布和代谢行为．结果表明，标记物能很快被组织吸收，其中头颅骨、胸骨、脊椎、四肢蜂窝、肝脏、脾摄取较高．除脑以外，在其他各脏器的清除速度均不快，化合物可能通过肾脏和消化道排泄．生物分布与Ｙａｍａｇｏ等人的实验结论不一致，讨论了造成差异的可能原因．Ｃ６０本身在多大程度上左右Ｃ６０衍生物在生物体内的分布，有待进一步的研究．
The biological activity of fullerene derivatives The results show that they may have great potential in the field of medical applications. In order to understand the distribution of C60 derivatives as carriers for drugs or drugs in vivo, a simple water-soluble derivative of C60, C60 (OH) x (O) y, was performed with the most clinically used imaging nuclide 99mTc Labeling of New Zealand White Rabbits with Marker Radioactivity Detected in Gut Organ and Tissues Using a γ Counter and SPECT (Single Photon Emission Computed Tomography) to Determine the Distribution of C60 Derivatives in Vivo And metabolic behavior. The results showed that the label can be quickly absorbed by the tissue, including skull, sternum, spine, limbs, honeycomb, liver, spleen uptake. In addition to the brain, the removal rate in other organs are not fast, compounds may be excreted through the kidneys and digestive tract. The biodistribution is inconsistent with that of Yamago et al., And the possible causes for the differences are discussed. The extent to which C60 itself contributes to the distribution of C60 derivatives in vivo remains to be further studied.