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目的:采用单光子发射计算机断层(SPECT)门控平衡法心血池心室造影,评价洛汀新(苯那普利)对急性心肌梗死(AMI)患者的心脏收缩、舒张功能及室壁瘤发生率的影响。方法:将同期住院的70例AMI患者随机分为两组,治疗组于发病72小时后开始服用洛汀新10mg,每日一次,连用6周后采用核素门控平衡法心血池心室造影,了解心脏收缩和舒张功能及室壁瘤发生率,并与对照组比较。结果:治疗组左室射血分数较对照组提高约20％(P<0.001),左室峰射血率提高(P<0.001)。在心脏收缩功能改善的同时,心脏舒张功能亦改善,左室峰充盈率较对照组提高(P<0.005)。治疗组患者梗死后心绞痛及室壁瘤发生率也较对照组明显下降。结论:洛汀新可以明显改善急性心肌梗死患者的心脏收缩及舒张功能,减少梗死后心绞痛和室壁瘤的发生。
OBJECTIVE: To evaluate the effects of Lotensin (benazepril) on cardiac contractility, diastolic function and the incidence of aneurysm in patients with acute myocardial infarction (AMI) by single-photon emission computed tomography (SPECT) gated ventricular cardioplegia Impact. Methods: Seventy patients with AMI who were hospitalized in the same period were randomly divided into two groups. The treatment group started taking Lotensin 10 mg once daily after 72 hours of onset and once a week for 6 weeks. The radionuclide ventriculography, To understand the cardiac systolic and diastolic function and the incidence of aneurysm, and compared with the control group. Results: The left ventricular ejection fraction increased by 20% (P <0.001) and left ventricular peak ejection rate (P <0.001) in the treatment group. Cardiac diastolic function was improved at the same time as systolic function was improved, and the rate of left ventricular peak filling was higher than that of the control group (P <0.005). In the treatment group, the incidence of angina pectoris and aneurysm after infarction was also significantly lower than that of the control group. Conclusion: Lotensin can significantly improve cardiac contractility and diastolic function in patients with acute myocardial infarction and reduce the incidence of post-infarction angina and aneurysm.