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目的通过检测急性脑梗死患者血清visfatin水平来探讨该因子与脑梗死的相关性及发病的关系。方法分为健康对照组(A组)和实验组(B组),根据测定的颈总动脉内膜中层厚度(IMT),B组又分为无动脉粥样硬化组(B1组)和动脉粥样硬化组(B2组),常规化验空腹血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血糖,用酶联免疫吸附试验(ELISA)法来测定各组血清visfatin水平,分析visfatin与脑梗死的相关性及发病的关系。结果 visfatin水平B组高于A组,B2组高于B1组,logistic回归分析示visfatin含量越高越容易患动脉粥样硬化。结论 visfatin可作为动脉粥样硬化的独立危险因素,高水平血清visfatin与脑梗死的发病相关。
Objective To explore the relationship between the factor and cerebral infarction by detecting the serum visfatin levels in patients with acute cerebral infarction. Methods According to the measured carotid artery intima-media thickness (IMT), group B was divided into group without atherosclerosis (group B1) and group with atherosclerosis (Group B2), routine test of fasting serum TC, TG, HDL-C, LDL-C, Serum visfatin levels were determined by enzyme linked immunosorbent assay (ELISA), and the relationship between visfatin and cerebral infarction was analyzed. Results The levels of visfatin in group B were higher than those in group A, while those in group B2 were higher than those in group B1. Logistic regression analysis showed that the higher the visfatin content, the more susceptible to atherosclerosis. Conclusion Visfatin can be used as an independent risk factor for atherosclerosis. High levels of serum visfatin are associated with the onset of cerebral infarction.