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目的:分析多囊卵巢综合征(PCOS)患者行体外受精-胚胎移植(IVF-ET)的结局及其影响因素。方法:对2010年1月～2011年10月在唐山市妇幼保健院生殖遗传科经预处理后行IVF-ET的PCOS不孕患者70周期和因输卵管因素行IVF-ET的159周期进行回顾性分析,比较两组患者的年龄、体重指数(BMI)、Gn起始剂量、Gn总量、Gn天数、HCG日的E2值、获卵数、MⅡ卵率、受精率、着床率及临床妊娠率。结果:PCOS组患者的Gn起始剂量、Gn总量小于对照组,Gn天数大于对照组(P<0.05);HCG日的E2值、获卵数高于对照组(P<0.05),但MⅡ卵率低于对照组;受精率、着床率、临床妊娠率与对照组相比无统计学差异(P>0.05)。结论:IVF-ET是难治性PCOS不孕的有效方法。
Objective: To analyze the outcome of IVF-ET and its influencing factors in patients with polycystic ovary syndrome (PCOS). Methods: A retrospective review was conducted on the 70 cycles of PCOS infertility patients with IVF-ET and the 159 cycles of IVF-ET due to tubal factors in the Department of Reproductive Genetics, Tangshan Maternal and Child Health Hospital from January 2010 to October 2011 The age, body mass index (BMI), initial dose of Gn, total amount of Gn, Gn days, E2 value on HCG day, number of oocytes retrieved, M Ⅱ egg rate, fertilization rate, implantation rate and clinical pregnancy were compared and analyzed. rate. Results: The initial dose of Gn and total Gn in PCOS group were less than those in control group, and Gn days were greater than that in control group (P <0.05). E2 value and number of oocytes retrieved on HCG day were higher than those in control group (P <0.05) There was no significant difference in fertilization rate, implantation rate and clinical pregnancy rate between the control group and the control group (P> 0.05). Conclusion: IVF-ET is an effective treatment for refractory PCOS infertility.