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目的探讨采用阿昔洛韦与纳洛酮联合方案进行治疗的小儿病毒性脑炎患者的临床效果。方法本组收集2013年4月—2015年3月接诊的病毒性脑炎80例患儿,通过随机数字列表法将所有患者随机分为对照组(40例)与研究组(40例)。两组患者入院确诊后均给予常规治疗,对照组40例患者在此基础上给予阿昔洛韦治疗,研究组40例患者则在对照组的治疗基础上给予纳洛酮联合治疗。观察及对比两组患儿的临床治疗效果。结果研究组患儿治疗的显效率与总有效率均显著高于对照组(P<0.05),研究组患儿治疗后的后遗症发生率显著低于对照组(P<0.05)。结论对小儿病毒性脑炎患儿采用阿昔洛韦与纳洛酮联合方案进行治疗具有良好的临床疗效,且后遗症发生率低,值得临床推广应用。
Objective To investigate the clinical efficacy of acyclovir combined with naloxone in the treatment of children with viral encephalitis. Methods Eighty children with viral encephalitis admitted from April 2013 to March 2015 were enrolled in this study. All patients were randomly divided into control group (40 cases) and study group (40 cases) by random number list method. Two groups of patients admitted to hospital after diagnosis were given conventional treatment, 40 patients in the control group were given acyclovir on this basis, 40 patients in the study group were treated with naloxone on the basis of the control group. The clinical effects of two groups were observed and compared. Results The effective rate and total effective rate of children in study group were significantly higher than those in control group (P <0.05). The incidence of sequelae of children in study group was significantly lower than that in control group (P <0.05). Conclusion The treatment of pediatric viral encephalitis with acyclovir combined with naloxone has a good clinical effect, and the incidence of sequelae is low, which is worthy of clinical application.