微透析技术作为一种新型的研究生物动态变化的活体采样技术,具有“在体、原位、实时、连续、高效”等特点。然而,该技术仍处于不断成熟的过程中,诸多问题仍待解决和完善,尤其是校正方法的稳定性和准确性。为此,该文就国内外有关微透析技术的基本装置、设计原理及其校正方法的研究概况予以综述,为相关研究工作提供科学依据和理论支持。 Microdialysis technology, as a new kind of live sampling technique to study biological dynamic changes, has such characteristics as “in vivo, in situ, real time, continuous and efficient”. However, the technology is still in the process of maturing. Many problems remain to be solved and improved, especially the stability and accuracy of the calibration method. Therefore, this paper reviews the basic research on the basic devices, design principles and correction methods of microdialysis at home and abroad, and provides scientific basis and theoretical support for the related research work.