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目的:初步研究鼻咽癌放疗对患者血压的影响及其机制。方法:随机抽取2011年12月至2014年3月收治本院的符合条件的60例鼻咽癌放治后患者及60例其他部位恶性肿瘤放疗后患者作为研究对象。统计分析患者放疗前及放疗1个月后的血压、心率等指标。结果:鼻咽癌放疗后组收缩压较放疗前组明显下降(P<0.05)。其他肿瘤放疗前后组收缩压比较,差异无统计学意义(P>0.05)。鼻咽癌组中血压下降率较其他部分肿瘤组明显偏高(P<0.05),颈部淋巴结肿大组血压下降与无颈部淋巴结肿大组比较,差异无统计学意义(P>0.05)。鼻咽癌组血压下降组放疗前后平均心率比较,差异无统计学意义(P>0.05)。其他肿瘤组血压下降组放疗前后平均心率比较,差异有统计学意义(P<0.05)。结论:血压下降情况在鼻咽癌放疗患者中较其他肿瘤患者放疗后常见,颈动脉窦受压可能是其一个重要原因。
Objective: To study the influence of nasopharyngeal carcinoma radiotherapy on blood pressure and its mechanism. Methods: Sixty eligible patients with NPC undergoing radiotherapy and 60 patients with malignant tumors at other sites underwent radiotherapy in our hospital from December 2011 to March 2014 were randomly selected as the study subjects. Statistical analysis of patients before radiotherapy and 1 month after radiotherapy blood pressure, heart rate and other indicators. Results: The systolic blood pressure of nasopharyngeal carcinoma after radiotherapy was significantly lower than that before radiotherapy (P <0.05). There was no significant difference in systolic blood pressure between other groups before and after radiotherapy (P> 0.05). The rate of decrease of blood pressure in nasopharyngeal carcinoma group was significantly higher than that in other tumor groups (P <0.05), while there was no significant difference in the decrease of blood pressure between cervical lymph node enlargement group and non-cervical lymph node enlargement group (P> 0.05) . The mean heart rate of nasopharyngeal carcinoma patients in descending blood pressure group before and after radiotherapy had no significant difference (P> 0.05). The average heart rate of other tumor patients before and after descending blood pressure was significantly different (P <0.05). Conclusion: The decline of blood pressure is more common in patients with radiotherapy of nasopharyngeal carcinoma than that of other patients after radiotherapy. The compression of the carotid sinus may be an important reason.