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胰高血糖素是一种含有29个氨基酸残基的直链多肽。它主要由胰岛α细胞分泌的。它在外周具有促进肝糖元分解引起血糖升高;激活脂肪酶使甘油三酯分解,引起血中自由脂肪酸(FFA)浓度增高等生理作用。近年来还发现,在大鼠、狗、猪、牛及人的下丘脑等也存在有胰高血糖素样物质,对于脑中这种肽的生理作用尚未见报道。本工作事先给家兔侧脑室埋藏套管,用慢性实验方法,向其侧脑室注射20微升含0.5～5微克的胰高血糖素溶液,观察在注射后的15、45、75、105分钟血糖、血浆FFA和胰岛素浓度的变化。
Glucagon is a linear peptide containing 29 amino acid residues. It is mainly secreted by pancreatic α-cells. It has in the periphery to promote liver glycogenolysis caused by elevated blood sugar; activated lipase triglyceride decomposition, causing blood free fatty acids (FFA) increased physiological functions. In recent years, it has also been found that glucagon-like substances also exist in the hypothalamus of rats, dogs, pigs, cattle and humans, and the physiological roles of such peptides in the brain have not been reported yet. This work in advance to the rabbit lateral ventricle buried casing, with chronic experimental methods, to the lateral ventricle injection of 20 microliters containing 0.5 to 5 micrograms of glucagon solution was observed after injection 15,45,75,105 minutes Blood glucose, plasma FFA and insulin concentration changes.