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早在一个世纪之前就有人提出血-迷路屏障这个概念,但至今对其性质尚未充分明瞭。近几年来曾在实验室内利用生理的、药理的方法进行了研究。作者们用栗鼠经麻醉后将~(22)钠、~(45)钙、血清蛋白~(125)碘、卡那霉素和速尿等经稀释后分别注入其体内;间隔一定时间后采集静脉血、外淋巴液、脑脊液及眼房水;将这些标本分别测定其含量。结果表明:渗入外淋巴的钠离子与脑脊液或房水相比是缓慢的,但在这三种液体中均可测得~(22)钠含量的升高,这证明血-迷路屏障的存在。如同时注入利尿酸可减低~(22)钠进入外淋巴的比率,这表明利尿酸可抑制钠离子从血液到外淋巴的转运。对钙测定的结果并无特殊;但由于钙对
As early as a century ago, there was a suggestion that the concept of blood-labyrinth barrier, but so far its nature has not been fully understood. In recent years, the use of physiological, pharmacological methods in the laboratory were studied. After being anesthetized with chinchillas, the rats were respectively injected into their bodies with ~ (22) sodium, ~45 calcium, serum protein ~ (125) iodine, kanamycin and furosemide after dilution. Blood, peripheral lymphatic fluid, cerebrospinal fluid and aqueous humor; these specimens were measured for its content. The results show that sodium infiltration into the perilymph is slow compared to cerebrospinal fluid or aqueous humor, but an increase in ~ (22) sodium is detectable in all three fluids, demonstrating the presence of a blood-labyrinth barrier. Simultaneous infusion of uric acid reduces the rate of ~ (22) sodium entry into the perilymph, suggesting that uricosuric acid inhibits sodium transport from the blood to the perilymph. The result of calcium determination is not specific; but due to calcium pair